Readers tell from experience
How do you deal with a hangover? We asked this of some men and women in the run up to their new year’s celebrations. Below are their responses and our explanations based on the science behind these hard-learned recommendations.
Drink vodka and water, i.e. choose your drink carefully.
You may have brushed off your high school chemistry classes, but there is one chemical that just won’t go away — acetaldehyde. Every drink eventually becomes acetaldehyde in the body when ethanol, the stuff that makes you high, is metabolised. Acetaldehyde is toxic and causes flushing, sweatiness, nausea, vomiting and an increased heart rate. It disrupts some important biological pathways such as gluconeogenesis. As its name suggests, gluconeogenesis makes new glucose. The brain is picky and will only accept energy in the form of glucose. When your drinking binge diverts the production of glucose for the brain, you feel lethargic, moody, weak, and unable to concentrate.
What does acetaldehyde have to do with vodka? Acetaldehyde and the other non-ethanol chemicals that make their way into booze are called congeners. Similar to acetaldehyde, other congeners contribute to the symptoms of a hangover. Vodka and gin have less of these, so are safer, less hangover-inducing drinks. The liquids with colour, smell and apparently more taste have higher amounts of congeners. Whisky, rum, red wine, and brandy (in that order) are the guilty lot.
Drink a lot of water before bed.
Ethanol is the reason you need to visit the bathroom soon after downing your spirits. It reduces the effect of a water-regulating hormone and tells your kidneys to let some water out. As a result, your blood becomes more concentrated. This has been blamed for some of the fatigue and headaches seen in hangovers. So, drink a lot of water.
Eat a lot of carbs.
As mentioned above, alcohol decreases gluconeogenesis by distracting the liver to break down ethanol. This keeps glucose levels low. Also, a long night of drinking can blunt the normal cortisol surge that gives early morning glucose and energy. The way to counter these effects is to keep munching. This is especially important for frequent heavy drinkers. They have lower levels of glucose stores in their bodies so are more susceptible to these glucose changes. This is why if you see someone pass out at a bar, ask the bartender to keep some sugar water ready.
Eat greasy burgers, fries and orange juice.
Add some raw or slightly poached eggs to that! Fats and proteins slow the absorption of alcohol. Eggs contain an important nutrient that gets wasted when you do — cysteine. Studies have shown that supplementing vitamin B1 and C as well as cysteine can protect against the toxic effects of acetaldehyde.
(This story appears in the 22 January, 2010 issue of Forbes India. To visit our Archives, click here.)