Various therapeutic strategies to manage cholesterol levels
Studies like the Framingham Study, MRFIT, and Seven Countries Study all demonstrate a connection between elevated blood cholesterol levels and cardiovascular events. LDL-C, in particular, has been linked to these events. Moreover, factors like smoking, high blood pressure, diabetes, obesity, and modified lipid metabolism can increase the risk of atherosclerosis. As a result, lowering LDL-C levels may help reduce the chance of myocardial infarction and other cardiovascular issues.
The LDL-C lowering strategies include the administration of therapeutics that inhibit cholesterol synthesis, such as:
To control lipoprotein(a), lowering strategies involve the administration of PCSK9 inhibitors, niacin, and CETP inhibitors or Lipoprotein apheresis.
The triglyceride levels can be controlled with the help of fibrates, niacin, and n-3 fatty acids.
LPL gene therapy -Alipogene tiparvovec is an adeno-associated virus serotype 1-based gene therapy used to control the lipid levels in the body.
Clinical research and studies have consistently emphasized that following a healthy lifestyle and keeping a check on potent risk factors can help reduce the risk of CVD, avert CVD-associated complications and prevent mortality.
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